Investigation of the role of monoclonal antibodies in the treatment of 4 Autoimmune diseases

The subject is Investigation of the role of monoclonal antibodies in the treatment of 4 autoimmune diseases. Introduction should include: -Pathophysiology of specific autoimmune disease -Molecular mechanisms, -Immune system + genetic factors that influence it for example (HLA,MHC) -Symptoms -Treatment conventional and new treatment with monoclonal antibodies, Diseases: 1) Hashimoto, 2) Rheumatoid arthritis,3) Diabetes, 4)Psoriasis or Inflammatory bowel disease Please note that for the Introduction I’m allowed to use peer-reviewed articles but they must be after 2015.