Describe the validity of using mice in this particular study. Would the mouse model be just as effective if hypothetically they were not looking at infections?
Describe the validity of using C. elegans in this particular study. Would the nematode model be just as effective if hypothetically they were not looking at infections.
What is the role of heparin in microbial infections? What is the role of heparin in Alzheimer’s disease? (i answered the first part, pls add to it and/or just answer the second part pls)
LL-37 contains a XBBXBX, which is exhibited in amyloid-B protein also, heparin-binding that mediates inhibition of host adhesion and agglutination by making it easier for attachment of oligomeric species to microbial cell wall of carbohydrates. Serious immunodeficiency associated with low LL-37 expression typically leads to fatal infections in childhood if untreated.