please answer the 4 questions – use only one page for each answer. – Part 2 – please answer the 3 questions – use up to two pages for each answer. – Do not use anything smaller than Times 12 point font. – Please submit one file for each answer. – use Van

You are a clinician-scientist that has a patient with colon cancer. Identify four possible oncogenes that are both commonly affected in colon cancer and are actionable for treatment with available drugs either directly or indirectly. Identify two appropriate FDA-approved kinase inhibitor drugs for counteracting the gain of function for each of these four oncogenes. Identify which of the most common cancer-inducing amino acid mutations on these four oncogenes you would initially screen for (3 mutations for each oncogene) in your patient to identify which kinase you will target with a drug that you would first prescribe for your patient. (You may find the www.onconet.ca, www.kinasenet.ca, www.drugkinet.ca and http://cancer.sanger.ac.uk/cosmic websites as well as the lecture notes helpful.)

 

Dr. Ong

Prostate cancer is exquisitely dependent on androgens for growth and survival.

1. Describe the endocrine regulation of androgen levels by the hypothalamic pituitary axis.

2. Describe the androgen/androgen receptor signalling pathway

3. Name two molecular targets for treatment of prostate cancer and how drugs that target these proteins work to block androgen dependent growth of prostate cancer