Cancer Models and Clinical Cancer Care,

Prostate cancer is exquisitely dependent on androgens for growth and survival. • Describe endrocrine regula@on of androgen levels – Hypothalamic pituitary axis • Describe androgen/androgen receptor signaling pathway • Name two molecular drug targets for treatment of prostate cancer and how drugs that target these proteins work to block androgen dependent growth of prostate cancer. (No need to memorize specific drug names.

Gene@cally engineered mouse models • Advances in gene@c engineering and mouse embryology • Rise in use of gene@cally engineered mouse models or GEMMS of human diseases including cancer • Transgenic over-expression (gain of func@on) of oncogenes • Gene dele@on (loss of func@on) of tumor suppressor genes